m-TOR inhibitors and risk of Pneumocystis pneumonia after solid organ transplantation: a systematic review and meta-analysis.
Identifieur interne : 000176 ( Main/Exploration ); précédent : 000175; suivant : 000177m-TOR inhibitors and risk of Pneumocystis pneumonia after solid organ transplantation: a systematic review and meta-analysis.
Auteurs : Maryam Ghadimi [Iran] ; Zinat Mohammadpour [Iran] ; Simin Dashti-Khavidaki [Iran] ; Alireza Milajerdi [Iran]Source :
- European journal of clinical pharmacology [ 1432-1041 ] ; 2019.
Descripteurs français
- KwdFr :
- MESH :
- antagonistes et inhibiteurs : Sérine-thréonine kinases TOR.
- épidémiologie : Pneumonie à Pneumocystis.
- Facteurs de risque, Humains, Pneumocystis carinii, Transplantation d'organe.
English descriptors
- KwdEn :
- MESH :
- chemical , antagonists & inhibitors : TOR Serine-Threonine Kinases.
- epidemiology : Pneumonia, Pneumocystis.
- Humans, Organ Transplantation, Pneumocystis carinii, Risk Factors.
Abstract
PURPOSE
Although there is controversy, some evidences proposed increased risk of post-transplant Pneumocystis carinii pneumonia (PCP) in patients receiving mammalian target of rapamycin (mTOR) inhibitors. This study aimed to examine the association between m-TOR inhibitors and the risk of developing PCP in solid organ transplant (SOT) recipients.
METHODS
A comprehensive search was performed to find the eligible studies that investigated the incidence of PCP in patients treated with mTOR inhibitors after SOT. Random effect model was applied for meta-analysis.
RESULTS
Combination of 15 effect sizes showed a significant positive association between mTOR inhibitor administration and the risk of PCP (OR = 1.90, 95%CIs = 1.44, 2.75). There was no heterogeneity between studies (I
CONCLUSION
In conclusion, administration of mTOR inhibitors is a potential risk factor for late-onset PCP after SOT. Targeted PCP prophylaxis based on recipients' risk factors rather universal prophylaxis may lessen the risk.
DOI: 10.1007/s00228-019-02730-0
PubMed: 31377892
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Box 1417614411, Tehran, Iran. dashtis@sina.tums.ac.ir.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box 1417614411, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Milajerdi, Alireza" sort="Milajerdi, Alireza" uniqKey="Milajerdi A" first="Alireza" last="Milajerdi">Alireza Milajerdi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author></analytic><series><title level="j">European journal of clinical pharmacology</title><idno type="eISSN">1432-1041</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Humans (MeSH)</term><term>Organ Transplantation (MeSH)</term><term>Pneumocystis carinii (MeSH)</term><term>Pneumonia, Pneumocystis (epidemiology)</term><term>Risk Factors (MeSH)</term><term>TOR Serine-Threonine Kinases (antagonists & inhibitors)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Facteurs de risque (MeSH)</term><term>Humains (MeSH)</term><term>Pneumocystis carinii (MeSH)</term><term>Pneumonie à Pneumocystis (épidémiologie)</term><term>Sérine-thréonine kinases TOR (antagonistes et inhibiteurs)</term><term>Transplantation d'organe (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>TOR Serine-Threonine Kinases</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Sérine-thréonine kinases TOR</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Pneumonia, Pneumocystis</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Pneumonie à Pneumocystis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Organ Transplantation</term><term>Pneumocystis carinii</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Facteurs de risque</term><term>Humains</term><term>Pneumocystis carinii</term><term>Transplantation d'organe</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>PURPOSE</b></p><p>Although there is controversy, some evidences proposed increased risk of post-transplant Pneumocystis carinii pneumonia (PCP) in patients receiving mammalian target of rapamycin (mTOR) inhibitors. This study aimed to examine the association between m-TOR inhibitors and the risk of developing PCP in solid organ transplant (SOT) recipients.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>A comprehensive search was performed to find the eligible studies that investigated the incidence of PCP in patients treated with mTOR inhibitors after SOT. Random effect model was applied for meta-analysis.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Combination of 15 effect sizes showed a significant positive association between mTOR inhibitor administration and the risk of PCP (OR = 1.90, 95%CIs = 1.44, 2.75). There was no heterogeneity between studies (I</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>In conclusion, administration of mTOR inhibitors is a potential risk factor for late-onset PCP after SOT. Targeted PCP prophylaxis based on recipients' risk factors rather universal prophylaxis may lessen the risk.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31377892</PMID><DateCompleted><Year>2020</Year><Month>03</Month><Day>09</Day></DateCompleted><DateRevised><Year>2020</Year><Month>03</Month><Day>09</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1432-1041</ISSN><JournalIssue CitedMedium="Internet"><Volume>75</Volume><Issue>11</Issue><PubDate><Year>2019</Year><Month>Nov</Month></PubDate></JournalIssue><Title>European journal of clinical pharmacology</Title><ISOAbbreviation>Eur J Clin Pharmacol</ISOAbbreviation></Journal><ArticleTitle>m-TOR inhibitors and risk of Pneumocystis pneumonia after solid organ transplantation: a systematic review and meta-analysis.</ArticleTitle><Pagination><MedlinePgn>1471-1480</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00228-019-02730-0</ELocationID><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">Although there is controversy, some evidences proposed increased risk of post-transplant Pneumocystis carinii pneumonia (PCP) in patients receiving mammalian target of rapamycin (mTOR) inhibitors. This study aimed to examine the association between m-TOR inhibitors and the risk of developing PCP in solid organ transplant (SOT) recipients.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A comprehensive search was performed to find the eligible studies that investigated the incidence of PCP in patients treated with mTOR inhibitors after SOT. Random effect model was applied for meta-analysis.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Combination of 15 effect sizes showed a significant positive association between mTOR inhibitor administration and the risk of PCP (OR = 1.90, 95%CIs = 1.44, 2.75). There was no heterogeneity between studies (I<sup>2</sup> = 3.5%). Subgroup analysis revealed increased risk of PCP after the first year of transplantation (P < 0.001).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">In conclusion, administration of mTOR inhibitors is a potential risk factor for late-onset PCP after SOT. Targeted PCP prophylaxis based on recipients' risk factors rather universal prophylaxis may lessen the risk.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ghadimi</LastName><ForeName>Maryam</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mohammadpour</LastName><ForeName>Zinat</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Liver Transplantation Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dashti-Khavidaki</LastName><ForeName>Simin</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Liver Transplantation Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. dashtis@sina.tums.ac.ir.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box 1417614411, Tehran, Iran. dashtis@sina.tums.ac.ir.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Milajerdi</LastName><ForeName>Alireza</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D017418">Meta-Analysis</PublicationType><PublicationType UI="D000078182">Systematic Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>08</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Eur J Clin Pharmacol</MedlineTA><NlmUniqueID>1256165</NlmUniqueID><ISSNLinking>0031-6970</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>EC 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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31377892" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a RapamycinFungusV1
| This area was generated with Dilib version V0.6.38. |  |